|
KMID : 0616120170480030187
|
|
Korean Journal of Pharmacognosy
2017 Volume.48 No. 3 p.187 ~ p.194
|
|
|
Anti-inflammatory and Antioxidant Effects of Clam Worm Extract Treated with Peptidoglycan
|
|
Kim Se-Woong
Sapkota Mahesh
Yang Ming
Li Liang
Soh Yun-Jo
|
|
|
Abstract
|
|
|
|
Peptidoglycan in inserts and mammals is well known to improve biological functions in the host`s immune system. However, it is unclear how Peptidoglycan exerted its anti-inflammatory capacity especially in clam worm (Marphysa sanguinea). In this experiment, the anti-inflammatory and antioxidant effects of clam worm extract treated with (PCWE) peptidoglycan (Micrococcus luteus) in RAW264.7 cells were examined by measuring MDA, catalase, SOD, GSH-Px and inflammatory cytokines (nitric oxide, iNOS, interleukin-1β and tumor necrosis factor-α). PCWE significantly increased the activities of catalase, SOD and GSH-Px and decreased the level of MDA. Interestingly, PCWE induced activities of SOD and GSH-Px more than clam worm extract without peptidoglycan (CWE). In addition, PCWE decreased NO production, iNOS, COX-2, TNF-α and IL-1β better than CWE. Taken together, these results indicate that PCWE has the potential as a natural antioxidant and a therapeutic for inflammation-related diseases.
|
|
|
KEYWORD
|
|
|
Peptidoglycan , Clam worm extract , Anti-inflammation , Antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|